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| 产地 | 中国/美国 |
| 品牌 | 康朗生物 |
| 货号 | KL804611 |
| 保存条件 | 常温保存 |
| CAS编号 | 474-25-9 |
| 保质期 | 12个月 |
鹅去氧胆酸
Product Name: Chenodeoxycholic acid
| 别名: | 脱氧鹅胆酸;鹅脱氧胆酸;3α,7α-二羟基胆质酸;3α,7α-二羟基-5-β-胆烷酸; 脱氧脲苷;护肝素 |
| CAS号: | 474-25-9 |
| 分子式: | C24H40O4 |
| 分子量: | 392.58 |
| MDL号: | MFCD00064142 |
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| 鹅去氧胆酸介绍: | Chenodeoxycholic Acid, Free Acid and its 7β-isomer ursodeoxycholic acid are potent (nanomolar affinity) selective inhibitors of DD2 (AKR1C2). These compounds were non-competitive inhibitors of AKR1D1 yielding Ki values of 3.2 μM for chenodeoxycholic acid. This chemical is a hydrophobic primary bile acid, which increases intracellular Ca2+ in rat hepatocyte couplets. Studies indicate that Chenodeoxycholic Acid induces apoptosis through a PKC dependent pathway. It is known that Chenodeoxycholic Acid is essential in the metabolism of cholesterol via activation of nuclear receptors. This bile acid can also bind to BABP with a stoichiometery of 1:2. Alternate studies indicate that chenodeoxycholic acid can inhibit the expression of IL-6 and cell viability in QBC939 cells. |
| 用途: | An apoptosis inducer via PKC-dependent signalling pathway. |
| 特定比重: | 1.128 |
| 贮存: | 密封避光保存。 |
| 敏感性: | 对光敏感 |
| 可溶性: | Soluble in ethanol (~20 mg/ml), methanol, acetone, glacial acetic acid, DMF, DMSO, and 1:1 DMF:PBS(pH 7.2) (~0.5 mg/ml). Insoluble in water. |
| 生化和生理学机理: | Chenodeoxycholic Acid (CDCA), is a hydrophobic primary bile acid that activates nuclear receptors involved in cholesterol metabolism. Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulates genes involved in lipid metabolism. EC50 concentrations for activation of FXR range from 13-34 μM. In cells, Chenodeoxycholic Acid also binds to bile acid binding proteins (BABP) with a reported stiochiometery of 1:2. Chenodeoxycholic Acid toxicity is linked to increased cellular glutathione levels and increased oxidative stress. Exposure of cells to excess Chenodeoxycholic Acid contributes to liver and intestinal cancers. |
鹅去氧胆酸
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